Phenotypes Associated with This Genotype

Genotype
MGI:3706336

• Allelic Composition: Ncr1^tm1Oman/Ncr1^tm1Oman
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:112394 )

• when infected with influenza A/PR8 virus, all homozygotes die within 9 days, compared to ~67% of wild-type and 58% of heterozygous littermates

immune system

decreased NK cell number ( J:112394 )

• 2 days after influenza infection, a marked reduction in NK cells in the blood is observed in mutants compared to wild-type; this correlates with increased percentages of NK cells in the lungs

• with time, numbers of NK cells in the blood increase to pre-infection levels while NK cells continue to increase in the lungs

impaired natural killer cell mediated cytotoxicity ( J:112394 )

• in vivo, killing of RMAS or RMA cells, both of which are NK cell-sensitive targets, is impaired compared to that in wild-type or heterozygotes; RMA cells are killed less efficiently than RMAS cells in mutants

• in vitro, splenocytes from mutants show little or no cytolytic activity against known NK cell target cell lines without activation by poly(I):poly(C) treatment

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:112394 )

• when infected with influenza A/PR8 virus, all homozygotes die within 9 days, compared to ~67% of wild-type and 58% of heterozygous littermates

hematopoietic system

decreased NK cell number ( J:112394 )

• 2 days after influenza infection, a marked reduction in NK cells in the blood is observed in mutants compared to wild-type; this correlates with increased percentages of NK cells in the lungs

• with time, numbers of NK cells in the blood increase to pre-infection levels while NK cells continue to increase in the lungs

impaired natural killer cell mediated cytotoxicity ( J:112394 )

• in vivo, killing of RMAS or RMA cells, both of which are NK cell-sensitive targets, is impaired compared to that in wild-type or heterozygotes; RMA cells are killed less efficiently than RMAS cells in mutants

• in vitro, splenocytes from mutants show little or no cytolytic activity against known NK cell target cell lines without activation by poly(I):poly(C) treatment