Phenotypes Associated with This Genotype

Genotype
MGI:3706335

• Allelic Composition: Itgb1^tm1Mll/Itgb1^tm1Mll; Tg(Wap-cre)1Gsc/0
• Genetic Background: involves: 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland morphology ( J:99405 )

♀ • at lactation day 5, mammary glands have defects in alveolar integrity, with detachment of luminal epithelial cells resulting in an 11-fold increase in luminally shed and bulging cells due to alterations in cell-basement membrane associations

♀ • the defect in alveolar integrity becomes more pronounced during a second lactation

♀ • density of the lobular-alveolar structures is decreased at day 5 of the first, and more strongly, the second lactation

abnormal mammary gland growth during lactation ( J:99405 )

♀ • luminal cell proliferation is reduced in mammary glands at day 5 of lactation

integument

abnormal mammary gland morphology ( J:99405 )

♀ • at lactation day 5, mammary glands have defects in alveolar integrity, with detachment of luminal epithelial cells resulting in an 11-fold increase in luminally shed and bulging cells due to alterations in cell-basement membrane associations

♀ • the defect in alveolar integrity becomes more pronounced during a second lactation

♀ • density of the lobular-alveolar structures is decreased at day 5 of the first, and more strongly, the second lactation

abnormal mammary gland growth during lactation ( J:99405 )

♀ • luminal cell proliferation is reduced in mammary glands at day 5 of lactation