Phenotypes Associated with This Genotype

Genotype
MGI:3704089

• Allelic Composition: Mgrn1^md-nc/Mgrn1^md-nc
• Genetic Background: involves: 101/H * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:116645 , J:15072 )

• reduced viability (J:116645)

• reduced viability (J:15072)

perinatal lethality, incomplete penetrance ( J:116645 )

• Background Sensitivity: 46% of homozygote die before birth or during the first 3 weeks of life in mixed background of 101 and C3H

postnatal lethality, incomplete penetrance ( J:116645 )

• Background Sensitivity: 46% of homozygote die before birth or during the first 3 weeks of life in mixed background of 101 and C3H

prenatal lethality, incomplete penetrance ( J:116645 )

• Background Sensitivity: 46% of homozygote die before birth or during the first 3 weeks of life in mixed background of 101 and C3H

nervous system

astrocytosis ( J:81466 )

• by 11 to 12 months of age, many brain regions exhibit moderate to severe astrocytosis

brain vacuoles ( J:81466 )

• vacuolization predominates in gray matter and is associated with neuronal loss, but preservation of architecture

spongiform encephalopathy ( J:81466 , J:116645 )

• progressive spongy degeneration, first apparent in the hippocampus CA3 region at 2 months of age, however no amyloid plaques are found (J:81466)

• vacuolization predominates in gray matter and is associated with neuronal loss, but preservation of architecture (J:81466)

• affected regions include cerebral cortex, hippocampus, thalamus, brain stem, caudate-putamen, and cerebellum granule layer (J:81466)

• adult-onset spongy degeneration of the central nervous system (J:116645)

growth/size/body

left pulmonary isomerism ( J:116645 )

• in some 12.5-18.5 d.p.c. homozygous embryos

lung situs inversus ( J:116645 )

• reversed lung situs in some 12.5-18.5 d.p.c. homozygous embryos

situs inversus ( J:116645 )

• found in a very small proportion (<1%) of adult homozygous mice

cardiovascular system

right aortic arch ( J:116645 )

• in 12.5-18.5 d.p.c. homozygous embryos

abnormal left subclavian artery morphology ( J:116645 )

• retroesophageal left subclavian artery in 12.5-18.5 d.p.c. homozygous embryo

thin myocardium ( J:116645 )

• in 12.5-18.5 d.p.c. homozygous embryos

abnormal coronary sinus morphology ( J:116645 )

• unroofed coronary sinus in 12.5-18.5 d.p.c. homozygous embryos

abnormal heart and great artery attachment ( J:116645 )

• malposition of the great arteries of the heart in 12.5-18.5 d.p.c. homozygous embryo

double outlet right ventricle ( J:116645 )

• in 12.5-18.5 d.p.c. homozygous embryos

atrial septal defect ( J:116645 )

• in 12.5-18.5 d.p.c. homozygous embryos

dextrocardia ( J:116645 )

• in some 12.5-18.5 d.p.c. homozygous embryos

mesocardia ( J:116645 )

• in some 12.5-18.5 d.p.c. homozygous embryos

ventricular septal defect ( J:116645 )

• in 12.5-18.5 d.p.c. homozygous embryos

pericardial effusion ( J:116645 )

• pericardial effusion in some 12.5-18.5 d.p.c. homozygous embryos

hemorrhage ( J:116645 )

• in 12.5-18.5 d.p.c. homozygous embryos

congestive heart failure ( J:116645 )

• n some 12.5-18.5 d.p.c. homozygous embryos caused by congenital heart defects

muscle

thin myocardium ( J:116645 )

• in 12.5-18.5 d.p.c. homozygous embryos

muscle weakness ( J:81466 )

respiratory system

left pulmonary isomerism ( J:116645 )

• in some 12.5-18.5 d.p.c. homozygous embryos

lung situs inversus ( J:116645 )

• reversed lung situs in some 12.5-18.5 d.p.c. homozygous embryos

pleural effusion ( J:116645 )

• pleural effusion in some 12.5-18.5 d.p.c. homozygous embryos

embryo

abnormal left-right axis patterning ( J:116645 )

• embryonic lethality resulted from congenital heart defects due to defective establishment and/or maintenance of the left-right axis

pigmentation

darkened coat color ( J:81466 , J:15051 )

• yellow pigment is completely absent resulting in a black coat (J:81466)

• darker coat and ears of non-albino mice (J:15051)

reproductive system

decreased litter size ( J:81466 )

homeostasis/metabolism

pericardial effusion ( J:116645 )

• pericardial effusion in some 12.5-18.5 d.p.c. homozygous embryos

pleural effusion ( J:116645 )

• pleural effusion in some 12.5-18.5 d.p.c. homozygous embryos

integument

darkened coat color ( J:81466 , J:15051 )

• yellow pigment is completely absent resulting in a black coat (J:81466)

• darker coat and ears of non-albino mice (J:15051)

curly vibrissae ( J:81466 , J:116645 , J:15051 )

cellular

astrocytosis ( J:81466 )

• by 11 to 12 months of age, many brain regions exhibit moderate to severe astrocytosis