immune system
• degranulation of bone marrow mast cells (BMMC) induced by antigen-receptor bound IgE crosslinking is 3- to 5-fold reduced compared to those in Ms4a2-heterozygous transgenic mice
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• mice show a weaker response (temperature drop) in a model of anaphlaxis (injections of IgE every 12 hours for 36 hours, then antigenic challenge)
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• Il-6 production in stimulated BMMCs is reduced compared to Ms4a2-heterozygous transgenic mice
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hematopoietic system
• degranulation of bone marrow mast cells (BMMC) induced by antigen-receptor bound IgE crosslinking is 3- to 5-fold reduced compared to those in Ms4a2-heterozygous transgenic mice
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