Phenotypes Associated with This Genotype

Genotype
MGI:3703018

• Allelic Composition: Hoxa1^tm5Mrc/Hoxa1⁺; Hoxb1^tm5Mrc/Hoxb1^tm5Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal reflex ( J:119279 )

• 17% of mice have a noticeably narrower range of whisker movements on one side

• 8% have a mutant-like eyelid closure reflex in one eye

paralysis ( J:119279 )

• some facial motor hypomorphism is observed; Hoxa1 haploinsufficiency is observed

nervous system

small facial motor nucleus ( J:119279 )

• haploinsufficient presumptive facial nuclei are smaller, rounder, and located more internally than wild-type

abnormal facial nerve morphology ( J:119279 )

• zygomatic and temporal branches of facial nerve in affected mutants are thinner and sometimes atypically formed, but rarely missing