Phenotypes Associated with This Genotype

Genotype
MGI:3703013

• Allelic Composition: \Hoxa1^tm3.1Mrc/\Hoxa1^{tm4(Hoxb1)Mrc}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal reflex ( J:119279 )

• in response to an air puff, mice display defects ranging from complete inability to operate eyelids to mild defects where only a narrow slit remains open; 72% of animals are severely affected

• all animals were unable to completely close eyelids (eyeblink reflex) on at least one side

• 44% of mutants exhibit unilateral constraint of most anterior whisking range in response to air puff stimulus

• 7% exhibited one-sided weakness of pinna retraction in response to stimulus

facial paralysis ( J:119279 )

• mice show completely penetrant partial facial paralysis

nervous system

abnormal facial nerve morphology ( J:119279 )

• in mice with a severe eyeblink defect, zygomatic branch of facial nerve is exceedingly thin or absent; sometimes the nerve takes an aberrant trajectory