Phenotypes Associated with This Genotype

Genotype
MGI:3702914

• Allelic Composition: Atm^tm1Mfl/Atm⁺
• Genetic Background: involves: 129T2/SvEms * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:78527 )

• elevated tumor incidence

• average age at onset 18.6 months

• varying tumor types including dermatoid cysts

increased ovary tumor incidence ( J:78527 )

♀ • 8% of total

increased adenoma incidence ( J:78527 )

• 13% of total

increased leukemia incidence ( J:78527 )

• 5% of total

increased lymphoma incidence ( J:78527 )

• 24% of total

increased sarcoma incidence ( J:78527 )

• 32% of total

• half of sarcomas are in Mammary glands

reproductive system

increased ovary tumor incidence ( J:78527 )

♀ • 8% of total

endocrine/exocrine glands

increased ovary tumor incidence ( J:78527 )

♀ • 8% of total