Phenotypes for olt MGI:3702677 MGI Mouse

reproductive system phenotype ( J:24774 )

N	• female fertility is normal

abnormal reproductive system morphology ( J:24774 )

decreased testis weight ( J:12215 )

abnormal gametogenesis ( J:24774 )

abnormal spermatogenesis ( J:12215 )

• germ cell numbers are normal up to stage VII

• significant drop in germ cell numbers after step 13

azoospermia ( J:24774 )

• no spermatozoa in testis or epididymis

abnormal spermatid morphology ( J:12215 )

• mature spermatids lack tail structures although manchettes do form

decreased spermatid number ( J:12215 )

• "homogenization resistant" testicular spermatids are significantly reduced in number

arrest of spermiogenesis ( J:18271 , J:30721 )

• arrested at stage of elongating spermatids (acrosome phase) (J:18271)

• aborted flagellum formation (J:18271)

(J:30721)

male infertility ( J:24774 )

• males are sterile

endocrine/exocrine gland phenotype ( J:12215 )

N	• testicular steroidogenesis is normal

decreased testis weight ( J:12215 )

integument phenotype ( J:142517 )

N	• dorsal hair in normal anagen stage at day 15 • normal vibrissae

abnormal hair growth ( J:142517 )

alopecia ( J:142517 )

• due to premature exit of anagen phase

retarded hair growth ( J:24774 )

• retarded growth of the ventral coat at 11 days

sparse hair ( J:142517 , J:24774 )

• conspicuously reduced in the lower ventral and medial femoral regions (J:142517)

• density of hair is slightly reduced dorsally (J:142517)

• sparse fur in adults (J:24774)

• females more affected than males (J:24774)

abnormal hair shaft morphology ( J:142517 )

• bent and coiled hair shafts in inguinal and medial femoral regions at postnatal day 15

• occasional dorsal hairs with bent and coiled hair shafts at postnatal day 15

abnormal hair cortex morphology ( J:142517 )

• incompletely keratinized

abnormal hair follicle morphology ( J:142517 )

abnormal hair follicle development ( J:142517 )

• no proliferation in narrow bulbs in the medial femoral region

• some apoptotic cells

decreased hair follicle number ( J:142517 )

• normal numbers at day 15

• become less abundant by 3 months of age

abnormal hair cycle catagen phase ( J:142517 )

• hair in inguinal and femoral regions is in catagen phase at postnatal day 15

abnormal epidermal layer morphology ( J:142517 )

• increased cell layers in regions with more pronounced alopecia