Phenotypes Associated with This Genotype

Genotype
MGI:3702556

• Allelic Composition: Gpr39^tm1Dgen/Gpr39^tm1Dgen
• Genetic Background: B6.129P2-Gpr39^tm1Dgen

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:119239 )

N • no significant difference in serum glucose or insulin compared to wild-type mice

increased circulating glucose level ( J:151806 )

• whether fed a low fat high sugar or high fat high sugar diet, mice exhibit increased circulating glucose levels in a fed state compared with similarly treated wild-type mice

decreased circulating insulin level ( J:151806 )

• whether fed a low fat high sugar or high fat high sugar diet, mice exhibit a 30% to 40% decrease in serum insulin levels 15 minutes following administration of glucose compared with similarly treated wild-type mice

• when fed a high fat high sugar diet, mice exhibit reduced insulin serum levels following intraperitoneal administration of glucose compared with similarly treated wild-type mice

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:151806 )

• when fed a high fat high sugar diet, mice fail to exhibit an increase in islet size or density compared with similarly treated wild-type mice

• however, islet glucose responsiveness is normal

behavior/neurological

behavior/neurological phenotype ( J:119239 )

N • food intake is indistinguishable from wild-type

growth/size/body

growth/size/body region phenotype ( J:119239 )

N • normal body weight and adiposity