Phenotypes Associated with This Genotype

Genotype
MGI:3702521

• Allelic Composition: Gsk3b^tm1Jrw/Gsk3b^tm1Jrw
• Genetic Background: involves: 129 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:119186 )

• all die neonatally, unlike in previous studies where homozygotes died during mid-gestation

craniofacial

palatal shelves fail to meet at midline ( J:119186 )

• at E16.5, palatal shelves have rotated but do not meet at the midline

cleft secondary palate ( J:119186 )

• complete cleft of the secondary palate

skeleton

abnormal sternum ossification ( J:119186 )

• delay in ossification of the sternum is more obvious at early stages but by E18.5 levels of ossification in the sternum are sometimes similar to wild-type controls although the ossification centers are often in abnormal locations

xiphoid process foramen ( J:119186 )

• often there are holes in the xiphoid cartilage

split sternum ( J:119186 )

• sternal bars are frequently bifurcated and the appearance of ossification centers is delayed

delayed bone ossification ( J:119186 )

• delayed ossification of the skull, ear bones, and cranial base

• delay in ossification of the sternum is more obvious at early stages but by E18.5 levels of ossification in the sternum are sometimes similar to wild-type controls

digestive/alimentary system

palatal shelves fail to meet at midline ( J:119186 )

• at E16.5, palatal shelves have rotated but do not meet at the midline

cleft secondary palate ( J:119186 )

• complete cleft of the secondary palate

growth/size/body

palatal shelves fail to meet at midline ( J:119186 )

• at E16.5, palatal shelves have rotated but do not meet at the midline

cleft secondary palate ( J:119186 )

• complete cleft of the secondary palate