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Phenotypes Associated with This Genotype
Genotype
MGI:3702490
Allelic
Composition		 Hey1tm1Kkb/Hey1tm1Kkb
Mesp1tm2(cre)Ysa/Mesp1+
Tg(CAG-cat,-Notch1)1Ysa/0
Genetic
Background		 involves: 129S7/SvEvBrd * C3H * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hey1tm1Kkb mutation (0 available); any Hey1 mutation (17 available)
Mesp1tm2(cre)Ysa mutation (3 available); any Mesp1 mutation (18 available)
Tg(CAG-cat,-Notch1)1Ysa mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal myocardial trabeculae morphology ( J:108444 )
• mutants exhibit impaired ventricular trabeculation, however there is much less trabeculation of the atrioventricular myocardium compared with mutants that are not null for Hey1
abnormal atrioventricular cushion morphology ( J:108444 )
• mutants exhibit ectopic appearance of cell masses in the atrioventricular cushion
abnormal interventricular septum morphology ( J:108444 )
• the interventricular septum is shifted to the right side

muscle
abnormal myocardial trabeculae morphology ( J:108444 )
• mutants exhibit impaired ventricular trabeculation, however there is much less trabeculation of the atrioventricular myocardium compared with mutants that are not null for Hey1

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory