Phenotypes Associated with This Genotype

Genotype
MGI:3702469

• Allelic Composition: Mesp1^tm2(cre)Ysa/Mesp1⁺; Tg(CAG-cat,-Notch1)1Ysa/0
• Genetic Background: involves: C3H * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:108444 )

• embryos do not develop beyond E10.5 and die before E11.5

cardiovascular system

abnormal myocardium layer morphology ( J:108444 )

• exhibit impaired myocardium of the atrioventricular canal

abnormal myocardial fiber morphology ( J:108444 )

• cardiac myofibrils are poorly formed

• mutants exhibit impaired ventricular myocardial differentiation

• the atrioventricular myocardial wall shows evidence of trabeculation

abnormal heart development ( J:108444 )

abnormal atrioventricular cushion morphology ( J:108444 )

• exhibit ectopic appearance of cell masses in the atrioventricular cushion

abnormal heart shape ( J:108444 )

• hearts are deformed in shape with a rough surface morphology

enlarged heart ( J:139209 )

abnormal heart ventricle morphology ( J:108444 )

abnormal trabecula carnea morphology ( J:108444 )

• exhibit abnormal accumulation of trabecular cells in the ventricular wall near the compact layer

abnormal interventricular septum morphology ( J:108444 )

• the interventricular septum is shifted to the right side

dilated heart left ventricle ( J:108444 )

• the left ventricle is expanded

decreased heart right ventricle size ( J:108444 )

• the right ventricle is reduced in size

muscle

abnormal myocardium layer morphology ( J:108444 )

• exhibit impaired myocardium of the atrioventricular canal

abnormal myocardial fiber morphology ( J:108444 )

• cardiac myofibrils are poorly formed

• mutants exhibit impaired ventricular myocardial differentiation

• the atrioventricular myocardial wall shows evidence of trabeculation

abnormal trabecula carnea morphology ( J:108444 )

• exhibit abnormal accumulation of trabecular cells in the ventricular wall near the compact layer

abnormal sarcomere morphology ( J:108444 )

• cardiac myofibrils show an unclear sarcomere structure

growth/size/body

enlarged heart ( J:139209 )