Phenotypes Associated with This Genotype

Genotype
MGI:3702274

• Allelic Composition: Rangap1^{Gt(U3neo)1B6Rul}/Rangap1^{Gt(U3neo)1B6Rul}
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:16895 )

• homozygous embryos arrest in development at ~E6

• almost no homozygous embryos are observed after E8.5, E11 or E13; most embryos are resorbed by E8.5

• only 2 homozygous embryos (both abnormal) are observed at E8.5

growth/size/body

decreased embryo size ( J:16895 )

• at E6.5, embryos are ~25-50% the size of normal embryos

• at E7.5, homozygous embryos are one fourth to one third the size of normal embryos

embryo

abnormal embryo development ( J:16895 )

• abnormal embryos are observed at E6.5

abnormal mesoderm development ( J:16895 )

• E7.5-8.5 mutants lack an obvious mesoderm layer

embryonic growth arrest ( J:16895 )

• homozygous embryos arrest in development at ~E6; however they continue to grow until E7-8.5

decreased embryo size ( J:16895 )

• at E6.5, embryos are ~25-50% the size of normal embryos

• at E7.5, homozygous embryos are one fourth to one third the size of normal embryos

abnormal embryonic epiblast morphology ( J:16895 )

• ectoderm surrounding proamniotic cavity shows little or no organization compared to controls

• embryonic cells appear less cohesive

abnormal ectoplacental cone morphology ( J:16895 )

• ectoplacental cone does not appear vascularized

absent ectoplacental cavity ( J:16895 )

• at E7.5, embryos lack a discernible ectoplacental cavity

abnormal extraembryonic coelom morphology ( J:16895 )

• at E7.5, embryos lack a discernible exocoelom

small proamniotic cavity ( J:16895 )

• at E6.5 and 7.5, embryos contain a small proamniotic cavity