Phenotypes Associated with This Genotype

Genotype
MGI:3701961

• Allelic Composition: Mug1^tm1Vln/Mug1^tm1Vln
• Genetic Background: B.129P2-Mug1^tm1Vln

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:57485 )

• on a choline and methionine-deficient powder diet supplemented with ethionine (CDE), mice show greater sensitivity/higher mortality than wild-type but less sensitivity than Pzp-deficient mice

immune system

abnormal cytokine level ( J:57485 )

• after 3 days of CDE diet, some cytokines are upregulated in pancreas of some affected mice

liver inflammation ( J:57485 )

• inflammatory cell infiltrate is observed after 2-3 days of CDE diet

• liver abnormalities are reversed by 4 days of normal diet

liver/biliary system

hepatic necrosis ( J:57485 )

• observed after 2-3 days of CDE diet, along with large vacuole formation and remains unchanged afterwards

liver inflammation ( J:57485 )

• inflammatory cell infiltrate is observed after 2-3 days of CDE diet

• liver abnormalities are reversed by 4 days of normal diet

homeostasis/metabolism

increased circulating amylase level ( J:57485 )

• after 66 hours of CDE diet, amylase plasma concentrations are higher than in controls

increased circulating lipase level ( J:57485 )

• after 66 hours of CDE diet, lipase plasma concentrations are higher than in controls

abnormal cytokine level ( J:57485 )

• after 3 days of CDE diet, some cytokines are upregulated in pancreas of some affected mice

cellular

hepatic necrosis ( J:57485 )

• observed after 2-3 days of CDE diet, along with large vacuole formation and remains unchanged afterwards