Phenotypes Associated with This Genotype

Genotype
MGI:3701137

• Allelic Composition: Thra^tm2Ven/Thra⁺
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal thyroid gland physiology ( J:72959 )

• similar to homozygotes, heterozygotes exhibit a mixed hyper- and hypothyroid phenotype, dependent on the tissue studied

decreased activity of thyroid gland ( J:72959 )

• heterozygotes show signs of hypothyroidism, including significantly reduced levels of free T3 T4, increased fat content, and skeletal defects associated with a late-onset growth retardation

increased activity of thyroid gland ( J:72959 )

• in addition to hypothyroidism, heterozygotes display features of hyperthyroidism, including reduced body weight, elevated heart rate, and increased body temperature

homeostasis/metabolism

decreased circulating thyroxine level ( J:72959 )

• both male and female heterozygotes show significantly reduced free T4 levels in serum, that are intermediate between those of wild-type and homozygous mutant mice

decreased circulating triiodothyronine level ( J:72959 )

• both male and female heterozygotes show significantly reduced free T3 levels in serum, that are intermediate between those of wild-type and homozygous mutant mice

• total T3 levels are significantly reduced only in female heterozygotes

decreased circulating insulin-like growth factor I level ( J:72959 )

• heterozygotes display significantly reduced serum IGF-I levels, that are intermediate between those of wild-type and homozygous mutant mice

increased body temperature ( J:72959 )

• heterozygotes display an increased body temperature (36.7 0.1 C) relative to wild-type mice (36.5 0.1 C)

abnormal thyroid-stimulating hormone level ( J:72959 )

• at 6-20 weeks, both male and female heterozygotes display inappropriately normal serum levels of TSH, suggesting an alteration in the pituitary-thyroid axis

growth/size/body

decreased body weight ( J:72959 )

• both female and male heterozygotes show a slightly reduced body weight from birth to adulthood relative to wild-type mice

obese ( J:72959 )

• adult heterozygotes are obese

postnatal growth retardation ( J:72959 )

• both female and male heterozygotes show a slightly delayed growth spurt during the first 9 weeks of life relative to wild-type mice

skeleton

decreased bone mineral density ( J:72959 )

• heterozygotes display decreased trabecular bone mineral density (BMD), as shown by a 17% reduction in proximal tibia

abnormal compact bone morphology ( J:72959 )

• heterozygotes exhibit decreased tibial cortical bone mineral content relative to wild-type mice

decreased compact bone area ( J:72959 )

• heterozygotes exhibit decreased tibial cortical bone periosteal and endosteal circumferences, and cortical area relative to wild-type mice

abnormal trabecular bone morphology ( J:72959 )

• heterozygotes display decreased trabecular bone mineral density (BMD), as shown by a 17% reduction in proximal tibia

adipose tissue

increased total body fat amount ( J:72959 )

• similar to homozygotes, heterozygotes show a significant increase in fat content (121%) relative to wild-type mice

cardiovascular system

increased heart rate ( J:72959 )

• heterozygotes display a 10% increase in basal heart rate relative to wild-type littemates, despite their lower serum T3 levels