Phenotypes Associated with This Genotype

Genotype
MGI:3701078

• Allelic Composition: Igh^tm1(PAX5)Mbu/Igh⁺; Pax5^tm1Mbu/Pax5^tm1Mbu
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:118111 )

• mice have partial block in development at pro-B cell to pre-B cells transition in bone marrow

decreased B cell number ( J:118111 )

• splenic B cell numbers were decreased by 6-fold compared to wild-type

immune system

immune system phenotype ( J:118111 )

N • early B cell block seen in Pax5-deficient mice is rescued, as shown by presence of IgM+IgD+ mature B cells

abnormal B cell differentiation ( J:118111 )

• mice have partial block in development at pro-B cell to pre-B cells transition in bone marrow

decreased B cell number ( J:118111 )

• splenic B cell numbers were decreased by 6-fold compared to wild-type