Phenotypes Associated with This Genotype

Genotype
MGI:3700914

• Allelic Composition: Tg(KRT5-Tert)8043Blas/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:69757 , J:96945 )

• epidermis is more susceptible to the development of skin tumors upon chemical carcinogenesis (DMBA + TPA), with an increase in the number of papillomas and an increase in mortality (J:69757)

• mutant mice are more susceptible to skin tumorigenesis induced by DMBA + TPA, developing about 1.5-fold more papillomas per mouse than wild-type at week 15 and papillomas progress to bigger lesions (J:96945)

enhanced wound healing ( J:69757 , J:96945 )

• epidermis shows an increase in wound healing rate compared to wild-type (J:69757)

neoplasm

increased incidence of tumors by chemical induction ( J:69757 , J:96945 )

• epidermis is more susceptible to the development of skin tumors upon chemical carcinogenesis (DMBA + TPA), with an increase in the number of papillomas and an increase in mortality (J:69757)

• mutant mice are more susceptible to skin tumorigenesis induced by DMBA + TPA, developing about 1.5-fold more papillomas per mouse than wild-type at week 15 and papillomas progress to bigger lesions (J:96945)

cellular

cellular phenotype ( J:69757 )

N • mutants exhibit normal telomere length

integument

skin hyperplasia ( J:69757 , J:96945 )

• TPA-treated skin shows a high number of skin keratinocyte layers (skin hyperplasia) that are not seen in controls, indicating a more sustained proliferative response of skin to TPA treatment (J:69757)