Phenotypes Associated with This Genotype

Genotype
MGI:3700845

• Allelic Composition: Terc^tm1Rdp/Terc^tm1Rdp; Tg(KRT5-Tert)8043Blas/0
• Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J * DBA/2 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal chromosome morphology ( J:96945 )

• mutants exhibit an increase in the frequency of chromosome aberrations in keratinocytes, in particular, of end-to-end fusions, breaks, and telomere associations

decreased telomere length ( J:96945 )

• keratinocytes exhibit a significant decrease in average telomere length compared with wild-type cells, similar to that seen in mutant Terc homozygotes

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:96945 )

• mutants are less susceptible to DMBA + TPA induced skin tumorigenesis, with only 40% developing papillomas compared to 80%, 72% and 86% of wild-type, Tg(KRT5-Tert)8043Blas mutants, and Terc homozygous mutants, respectively

• the number of papillomas per mouse at week 15 is reduced compared to the above controls and papillomas never progress to lesions larger than 3 mm

delayed wound healing ( J:96945 )

• mutants exhibit a delayed rate of wound healing in skin compared to Tg(KRT5-Tert)8043Blas mutants

neoplasm

decreased incidence of tumors by chemical induction ( J:96945 )

• mutants are less susceptible to DMBA + TPA induced skin tumorigenesis, with only 40% developing papillomas compared to 80%, 72% and 86% of wild-type, Tg(KRT5-Tert)8043Blas mutants, and Terc homozygous mutants, respectively

• the number of papillomas per mouse at week 15 is reduced compared to the above controls and papillomas never progress to lesions larger than 3 mm