Phenotypes Associated with This Genotype

Genotype
MGI:3700829

• Allelic Composition: Thra^tm2Ven/Thra⁺; Thrb^tm1Df/Thrb^tm1Df
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

postnatal growth retardation ( J:118402 )

• mutant mice exhibit a less severely retarded weight gain over the first 4 postnatal weeks relative to Thra^tm2Ven homozygotes

• no significant difference in postnatal weight gain is noted by 5 weeks

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:118402 )

N • at 7-17 weeks of age, mutant mice display normal ABR thresholds in response to click or pure-tone (8, 16, 32 kHz) stimuli, indicating suppression of the auditory defect observed in single Thrb^tm1Df homozygotes

N • Background Sensitivity: on a mixed genetic background of equal parts 129/Sv, 129OlaHsd, BALB/c, and C57BL/6J strains, ABR responses are similar but more variable than those observed on a congenic C57BL/6J background

N • consistent with rescued ABR thresholds, the developmental expression of the I_K,f potassium current in cochlear IHCs is also largely corrected at P30 relative to single Thrb^tm1Df homozygotes