Phenotypes Associated with This Genotype

Genotype
MGI:3700749

• Allelic Composition: Cacng2^stg/Cacng2^stg
• Genetic Background: involves: A/J * C3HeB/FeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:121463 )

N • synaptic electrophysiology including neurotransmitter release and end plate potentials, as well as responses to channel inhibitors is not different from wild-type NMJs

abnormal motor neuron morphology ( J:121463 )

• fiber diameter at diaphragm NMJs (14.2 um) is slightly reduced compared with wild-type (15.8 um)

abnormal neuromuscular synapse morphology ( J:121463 )

• neuromuscular junction area (area staining for acetylcholine receptors) in ~25% smaller relative to wild-type mice (333 um² vs 446 um²)

abnormal CNS synaptic transmission ( J:106959 )

• peak current densities of low voltage-activated (LVA) calcium channels in thalamocortical neurons at membrane potential of -50 mV are increased by 45% compared to control

• peak current densities of high voltage calcium channels (HVA) in TC neurons are increased compared to wild-type