nervous system
N |
• synaptic electrophysiology including neurotransmitter release and end plate potentials, as well as responses to channel inhibitors is not different from wild-type NMJs
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• fiber diameter at diaphragm NMJs (14.2 um) is slightly reduced compared with wild-type (15.8 um)
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• neuromuscular junction area (area staining for acetylcholine receptors) in ~25% smaller relative to wild-type mice (333 um2 vs 446 um2)
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• peak current densities of low voltage-activated (LVA) calcium channels in thalamocortical neurons at membrane potential of -50 mV are increased by 45% compared to control
• peak current densities of high voltage calcium channels (HVA) in TC neurons are increased compared to wild-type
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