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Phenotypes Associated with This Genotype
Genotype
MGI:3700665
Allelic
Composition
Slc40a1ffe/Slc40a1+
Genetic
Background
either: (involves: 129X1/SvJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6J)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc40a1ffe mutation (0 available); any Slc40a1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• serum ferritin levels are increased 10-fold compared to wild-type mice at 6 months of age and levels continue to increase with age (J:118592)
• serum ferritin levels are increased 10-fold compared to wild-type mice at 6 months of age and levels continue to increase with age (J:118592)
• at 6 months of age transferrin saturation in serum is much lower than in wild-type mice (J:118592)
• at 6 months of age transferrin saturation in serum is much lower than in wild-type mice (J:118592)
• aged mice accumulate high levels of iron in Kupffer cells (J:118592)
• aged mice accumulate high levels of iron in Kupffer cells (J:118592)

hematopoietic system
• mild anemia (J:118592)
• mild anemia (J:118592)
• some hypochromic red cells are present in blood smears (J:118592)
• some hypochromic red cells are present in blood smears (J:118592)
• some hypochromic red cells with variable size are present in blood smears (J:118592)
• some hypochromic red cells with variable size are present in blood smears (J:118592)
• some target cells are present in blood smears (J:118592)
• some target cells are present in blood smears (J:118592)
• iron loaded macrophages are not able to export iron as efficiently as wild-type cells (J:118592)
• iron loaded macrophages are not able to export iron as efficiently as wild-type cells (J:118592)

immune system
• iron loaded macrophages are not able to export iron as efficiently as wild-type cells (J:118592)
• iron loaded macrophages are not able to export iron as efficiently as wild-type cells (J:118592)

liver/biliary system
• aged mice accumulate high levels of iron in Kupffer cells (J:118592)
• aged mice accumulate high levels of iron in Kupffer cells (J:118592)

Mouse Models of Human Disease
OMIM ID Ref(s)
Hemochromatosis, Type 4; HFE4 606069 J:118592


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory