Mouse Genome Informatics
ht
    Slc40a1ffe/Slc40a1+
either: (involves: 129X1/SvJ * C57BL/6J) or (involves: C3H/HeJ * C57BL/6J)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• serum ferritin levels are increased 10-fold compared to wild-type mice at 6 months of age and levels continue to increase with age
• at 6 months of age transferrin saturation in serum is much lower than in wild-type mice
• aged mice accumulate high levels of iron in Kupffer cells

hematopoietic system
• some hypochromic red cells are present in blood smears
• some hypochromic red cells with variable size are present in blood smears
• some target cells are present in blood smears
• mild anemia
• iron loaded macrophages are not able to export iron as efficiently as wild-type cells

immune system
• iron loaded macrophages are not able to export iron as efficiently as wild-type cells

liver/biliary system
• aged mice accumulate high levels of iron in Kupffer cells

Mouse Models of Human Disease
OMIM IDRef(s)
Hemochromatosis, Type 4; HFE4 606069 J:118592