About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3700376
Allelic
Composition		 Faddtm1Mpa/Faddtm1Mpa
Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa
Tg(Alb1-cre)7Gsc/0
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faddtm1Mpa mutation (0 available); any Fadd mutation (19 available)
Ikbkgtm1.1Mpa mutation (1 available); any Ikbkg mutation (15 available)
Tg(Alb1-cre)7Gsc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating alanine transaminase level ( J:118336 )
• spontaneous serum ALT levels are decreased compared to single Ikbkg mutants at 8 weeks of age
abnormal enzyme/coenzyme activity ( J:118336 )
• mice show increased JNK kinase activity

immune system
liver inflammation ( J:118336 )
• completely absent compared to single Ikbkg mutants at 8 weeks of age

liver/biliary system
liver/biliary system phenotype ( J:118336 )
N
• liver inflammation, hepatocyte apoptosis, increased hepatocyte proliferation, and focal lipid accumulation are inhibited in mutants compared to Ikbkg single mutants
liver inflammation ( J:118336 )
• completely absent compared to single Ikbkg mutants at 8 weeks of age

cellular
decreased apoptosis ( J:118336 )
• double mutants are protected from LPS-induced hepatocyte apoptosis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory