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Phenotypes Associated with This Genotype
Genotype
MGI:3700375
Allelic
Composition
Ikbkgtm1.1Mpa/Ikbkgtm1.1Mpa
Tg(Alb1-cre)7Gsc/0
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkgtm1.1Mpa mutation (1 available); any Ikbkg mutation (14 available)
Tg(Alb1-cre)7Gsc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• 8 week old mice show signs of steatohepatitis in the liver, characterized by immune cell infiltration into the parenchyma
• in 8-week old mice, hepatocytes show features of large-cell dysplasia with strong anisokaryosis; large areas of irregularly shaped glycogen deposits are detected
• at 6 months, livers show macroscopic nodules
• focal areas of lipid accumulation and low-grade dysplastic nodules with expansive growth are observed
• at 6 months, hepatocytes show lipid deposition and ballooning
• in 8-week old mice, hepatocytes show features of large-cell dysplasia with strong anisokaryosis; large areas of irregularly shaped glycogen deposits are detected
• at 6 months, mice show signs of steatosis and increased lipid deposition in hepatocytes
• multiple tumors are found in livers of 12-month old males; malignant liver tumors are present in all mice examined
• average number of tumors per mouse is 5.75 with average size of 8.58 mm
• tumors show expansive growth, increased cellularity, broad trabecular growth pattern in 4 to 6 layers, eosinophilia, higher cytoplasmic index compared to non malignant areas, and complete absence of portal tracts
• tumors show increased proliferation and higher mitotic indices (~1.44 per high-power field)
• tumors at 9 months show dysplastic foci and nodules

neoplasm
• multiple tumors are found in livers of 12-month old males; malignant liver tumors are present in all mice examined
• average number of tumors per mouse is 5.75 with average size of 8.58 mm
• tumors show expansive growth, increased cellularity, broad trabecular growth pattern in 4 to 6 layers, eosinophilia, higher cytoplasmic index compared to non malignant areas, and complete absence of portal tracts
• tumors show increased proliferation and higher mitotic indices (~1.44 per high-power field)
• tumors at 9 months show dysplastic foci and nodules

immune system
• cytokine expression is upregulated in mutants
• upon LPS injection, NF kappa b activation is completely absent
• following exposure to LPS, mice exhibit increased liver failure and hepatocyte apoptosis compared to similarly treated wild-type mice
• 8 week old mice show signs of steatohepatitis in the liver, characterized by immune cell infiltration into the parenchyma
• in 8-week old mice, hepatocytes show features of large-cell dysplasia with strong anisokaryosis; large areas of irregularly shaped glycogen deposits are detected

cellular
• mitochondria of hepatocytes appear swollen and display a reduction in mitochondrial crests compared to wild-type at 8 weeks of age
• 8-week old mice show an increase in apoptotic cells in the liver
• livers show increased proliferation
• at 8 weeks, there is a significant increase in progenitor cells and activation of oval cells in the liver

homeostasis/metabolism
• mice show a decrease in spontaneous serum glucose levels compared to controls
• mice show elevated serum levels of alanine aminotransferase (ALT) at 3 weeks, indicative of hepatocyte damage; ALT levels are further increased at 8 weeks
• mice show increased JNK kinase activity

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
fatty liver disease DOID:9452 OMIM:228100
J:118336


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory