Phenotypes Associated with This Genotype

Genotype
MGI:3700279

• Allelic Composition: Tnc^tm1Sia/Tnc^tm1Sia
• Genetic Background: involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired swimming ( J:32517 )

• at P21-P28, most homozygotes exhibit a poor swimming behavior that is not improved through repeated training

• i.p. administration of the 5-HT receptor agonist, DOI hydrochloride, transiently improves swimming behavior in 85% of poor swimmers

increased locomotor activity ( J:32517 )

• at P21-P28, most homozygotes display a 2-3-fold increase in locomotive activities relative to wild-type mice

• homozygotes keep on moving even during daytime

• i.p. administration of the dopamine receptor agonist, LY171555 (0.5 mg/kg, BW), prevents emergence of hyperlocomotion in mutant mice, with no behavioral changes in wild-type or heterozygous mice

increased stereotypic behavior ( J:32517 )

• at P21-P28, most homozygotes display stereotyped turning behavior, such as purposeless movements

abnormal circadian behavior ( J:32517 )

• homozygotes display an ambiguous circadian rhythm

homeostasis/metabolism

decreased dopamine level ( J:32517 )

• homozygotes with abnormal behavior exhibit a significantly reduced dopamine turnover rate in the striatum and hippocampus

abnormal serotonin level ( J:32517 )

• homozygotes with abnormal behavior exhibit a decreased serotonin (5-HT) turnover rate in the cerebral cortex and hippocampus

nervous system

abnormal CNS synaptic transmission ( J:32517 )

• homozygotes with abnormal behavior display reduced serotonin (5-HT) and dopamine (DA) neurotransmission in the cerebral cortex, hippocampus, and striatum