Phenotypes Associated with This Genotype

Genotype
MGI:3700258

• Allelic Composition: Chrna4^tm1Jbou/Chrna4⁺
• Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J) or (involves: 129X1/SvJ * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavioral arrest ( J:118273 )

• observed during seizures

seizures ( J:118273 )

• mice exhibit spontaneous recurrent seizures, ranging from 1-5s of behavioral arrest to extended (2-60 seconds) of rhythmic jerking movements of extremities, with loss of balance and falling over

clonic seizures ( J:118273 )

nervous system

abnormal nervous system physiology ( J:118273 )

seizures ( J:118273 )

• mice exhibit spontaneous recurrent seizures, ranging from 1-5s of behavioral arrest to extended (2-60 seconds) of rhythmic jerking movements of extremities, with loss of balance and falling over

clonic seizures ( J:118273 )

abnormal brain wave pattern ( J:118273 )

• mutants show abnormal EEG activity during seizure episodes, such as repetitive discharges with paroxysmal onset and sudden termination with asymmetric rhythm patterns; this is observed for 22% of a 4-hour recording period

abnormal inhibitory postsynaptic currents ( J:118273 )

• frequency and amplitude of spontaneous IPSCs are increased in pyramidal cells with application of nicotine; mean inhibitory current is increased 23.4-fold with nicotine treatment vs 2.5-fold in wild-type cells