Phenotypes Associated with This Genotype

Genotype
MGI:3700170

• Allelic Composition: Tlr1^tm1Aki/Tlr1^tm1Aki
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine secretion ( J:103395 )

• macrophages show impaired proinflammatory cytokine production in response to the native mycobacterial 19-kDa lipoprotein and a synthetic triacylated lipopeptide, but respond normally to diacylated lipoprotein

decreased interleukin-6 secretion ( J:103395 )

• macrophages show impaired IL-6 production in response to the native mycobacterial 19-kDa lipoprotein and a synthetic triacylated lipopeptide, but respond normally to diacylated lipoprotein

decreased tumor necrosis factor secretion ( J:103395 )

• macrophages show impaired TNF-alpha production in response to the native mycobacterial 19-kDa lipoprotein and a synthetic triacylated lipopeptide, but respond normally to diacylated lipoprotein