Phenotypes Associated with This Genotype

Genotype
MGI:3700139

• Allelic Composition: Ddit3^tm1Dron/Ddit3^tm1Dron
• Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased apoptosis ( J:52729 )

• homozygotes treated with tunicamycin to induce ER stress and renal insufficiency exhibit decreased programmed cell death in the renal proximal tubular epithelium

decreased fibroblast apoptosis ( J:52729 )

• MEFs prepared from E13.5 embryos exhibit less programmed cell death when challenged with agents that perturb ER function

homeostasis/metabolism

abnormal response to injury ( J:52729 )

• homozygotes treated with tunicamycin to induce ER stress and renal insufficiency exhibit decreased programmed cell death in the renal proximal tubular epithelium compared to controls despite impaired renal function