Phenotypes Associated with This Genotype

Genotype
MGI:3700135

• Allelic Composition: Trp53^tm3Wahl/Trp53^tm3Wahl
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:108183 )

N • no significant loss of homozygotes is detected at birth

cellular

abnormal cell cycle ( J:108183 , J:118244 )

• MEFs fail to arrest after irradiation or exposure to concentrations of adriamycin that induce arrest in wild-type cells (J:108183)

• MEFs fail to arrest after exposure to 6 Gy or 12 Gy irradiation (J:118244)

decreased cellular sensitivity to gamma-irradiation ( J:118244 )

• 10 Gy of whole body irradiation results in practically no thymocyte apoptosis unlike in wild-type mice where about 1/3 of thymocytes are apoptotic

• MEFs fail to arrest after exposure to 6 Gy or 12 Gy irradiation

decreased apoptosis ( J:108183 , J:118244 )

• adriamycin-induced apoptosis is significantly reduced at low (0.25 ug/ml) but not at high (0.5 and 1.0 ug/ml) concentrations of adriamycin compared to wild-type cells (J:108183)

• irradiation with 6 Gy or 12 Gy induces a smaller but still measurable level of apoptosis compared to wild-type cells (J:108183)

increased cell proliferation ( J:108183 )

• MEFs fail to undergo replicative senescence

neoplasm

increased tumor latency ( J:108183 )

• onset of tumor development is delayed compared to Trp53^tm1Brd homozygotes

homeostasis/metabolism

decreased cellular sensitivity to gamma-irradiation ( J:118244 )

• 10 Gy of whole body irradiation results in practically no thymocyte apoptosis unlike in wild-type mice where about 1/3 of thymocytes are apoptotic

• MEFs fail to arrest after exposure to 6 Gy or 12 Gy irradiation