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Phenotypes Associated with This Genotype
Genotype
MGI:3699817
Allelic
Composition
Fgfr2tm1Schl/Fgfr2+
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm1Schl mutation (0 available); any Fgfr2 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Crouzon-Like Syndrome characterization, skull scan and histological sections of Fgfr2tm1Schl/Fgfr2+ and Fgfr2tm2Schl/Fgfr2+ mice

craniofacial
• facial region is significantly shortened
• mice have rounded cranium
• coronal sutures are fused completely on both sides of the skull
• 1-week old mice have abundant mineralized bone trabeculae in the coronal suture mesenchyme

skeleton
• mice have rounded cranium
• coronal sutures are fused completely on both sides of the skull
• 1-week old mice have abundant mineralized bone trabeculae in the coronal suture mesenchyme
• mice display craniosynostosis

vision/eye
• mice have protruding eyes

Mouse Models of Human Disease
OMIM ID Ref(s)
Crouzon Syndrome 123500 J:118299


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory