Mouse Genome Informatics
ht
    Fgfr2tm1Schl/Fgfr2+
involves: 129S1/Sv
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Crouzon-Like Syndrome characterization, skull scan and histological sections of Fgfr2tm1Schl/Fgfr2+ and Fgfr2tm2Schl/Fgfr2+ mice

craniofacial
• facial region is significantly shortened
• mice have rounded cranium
• coronal sutures are fused completely on both sides of the skull
• 1-week old mice have abundant mineralized bone trabeculae in the coronal suture mesenchyme

skeleton
• mice have rounded cranium
• coronal sutures are fused completely on both sides of the skull
• 1-week old mice have abundant mineralized bone trabeculae in the coronal suture mesenchyme
• mice display craniosynostosis

vision/eye
• mice have protruding eyes

Mouse Models of Human Disease
OMIM IDRef(s)
Crouzon Syndrome 123500 J:118299