Phenotypes Associated with This Genotype

Genotype
MGI:3699364

• Allelic Composition: Ppp4c^tm1Tht/Ppp4c^tm1Tht; Tg(Lck-cre)548Jxm/0; Tg(TcraTcrb)425Cbn/0
• Genetic Background: involves: BALB/c * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal positive T cell selection ( J:117684 )

• only marginal increase in numbers of CD4 positive thymocytes is observed compared to TCR-transgenic mice

• CD4 SP/DP ratio is 0.29 compared to 0.46 in controls, indicating reduced positive selection

decreased double-positive T cell number ( J:117684 )

• a significant decrease in unfractionated, double-positive thymocyte numbers compared to single transgenic littermates abnormal CD4 T cell morphology

decreased single-positive T cell number ( J:117684 )

• significant decrease in SP cell numbers

immune system

abnormal positive T cell selection ( J:117684 )

• only marginal increase in numbers of CD4 positive thymocytes is observed compared to TCR-transgenic mice

• CD4 SP/DP ratio is 0.29 compared to 0.46 in controls, indicating reduced positive selection

decreased double-positive T cell number ( J:117684 )

• a significant decrease in unfractionated, double-positive thymocyte numbers compared to single transgenic littermates abnormal CD4 T cell morphology

decreased single-positive T cell number ( J:117684 )

• significant decrease in SP cell numbers