Phenotypes Associated with This Genotype

Genotype
MGI:3699363

• Allelic Composition: Ppp4c^tm1Tht/Ppp4c^tm1Tht; Tg(Lck-cre)548Jxm/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:117684 )

• developmental block specifically occurs at the double negative (DN) stage

• decreased percentage of TCR beta^hiCD3^hi mature thymocytes as well as decreased cell numbers are observed

abnormal positive T cell selection ( J:117684 )

• percentage of cells undergoing positive selection is decreased by ~60% compared to controls

• significant decrease in mature SP cell numbers

increased double-negative T cell number ( J:117684 )

• numbers of double negative (DN) cells are comparable to controls; however higher percentage of DN cells result

decreased double-positive T cell number ( J:117684 )

• a significant decrease in unfractionated double-positive thymocyte numbers compared to Tg-negative littermates; 70% decrease is observed accompanying the developmental block

decreased CD4-positive, alpha-beta T cell number ( J:117684 )

• significant decrease in numbers

decreased CD8-positive, alpha-beta T cell number ( J:117684 )

• significant decrease in numbers

decreased single-positive T cell number ( J:117684 )

• numbers of CD3+, Cd4+, and CD8+ T cells are decreased by ~50-60% in spleen and lymph nodes

abnormal T cell activation ( J:117684 )

• antigen-specific T cell activation is decreased, with decreased proliferation in response to antigen observed

hematopoietic system

abnormal T cell differentiation ( J:117684 )

• developmental block specifically occurs at the double negative (DN) stage

• decreased percentage of TCR beta^hiCD3^hi mature thymocytes as well as decreased cell numbers are observed

abnormal positive T cell selection ( J:117684 )

• percentage of cells undergoing positive selection is decreased by ~60% compared to controls

• significant decrease in mature SP cell numbers

increased double-negative T cell number ( J:117684 )

• numbers of double negative (DN) cells are comparable to controls; however higher percentage of DN cells result

decreased double-positive T cell number ( J:117684 )

• a significant decrease in unfractionated double-positive thymocyte numbers compared to Tg-negative littermates; 70% decrease is observed accompanying the developmental block

decreased CD4-positive, alpha-beta T cell number ( J:117684 )

• significant decrease in numbers

decreased CD8-positive, alpha-beta T cell number ( J:117684 )

• significant decrease in numbers

decreased single-positive T cell number ( J:117684 )

• numbers of CD3+, Cd4+, and CD8+ T cells are decreased by ~50-60% in spleen and lymph nodes

abnormal T cell activation ( J:117684 )

• antigen-specific T cell activation is decreased, with decreased proliferation in response to antigen observed