Phenotypes Associated with This Genotype

Genotype
MGI:3699290

• Allelic Composition: Sulf2^{Gt(XST155)Byg}/Sulf2^{Gt(XST155)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:117689 )

• at 3 weeks, number of homozygous mice is 48% of wild-type and only 29% of expected Mendelian number

embryonic lethality during organogenesis, incomplete penetrance ( J:117689 )

• significantly fewer homozygous embryos are found at E13.5 and 14.5; dead embryos appear to have terminated sometime from E10.5 to 12.5

growth/size/body

decreased embryo size ( J:117689 )

• many homozygous embryos and their placentas are smaller than wild-type embryos

• Background Sensitivity: at N3F3 generation (intercross of hets after third backcross to B6), expected number of homozygotes is obtained

decreased body size ( J:117689 )

• some homozygous pups (6/8 total runted pups) are severely runted with weights ~50% that of littermates at birth; runted mice are euthanized at various time points for health reasons

decreased body weight ( J:117689 )

• many homozygotes appear smaller than littermates after weaning, and weigh significantly less than wild-type littermates at 41.5 days

• at 1 year, homozygous mice have weights ~25% lower than littermates

embryo

decreased embryo size ( J:117689 )

• many homozygous embryos and their placentas are smaller than wild-type embryos

• Background Sensitivity: at N3F3 generation (intercross of hets after third backcross to B6), expected number of homozygotes is obtained

respiratory system

abnormal lung development ( J:117689 )

• 3 runted mice exhibited enlarged airspaces

respiratory distress ( J:117689 )

• a portion of runted homozygotes gasp after birth, suggesting respiratory distress and lung problems