Phenotypes Associated with This Genotype

Genotype
MGI:3699226

• Allelic Composition: Sall1^tm1Ryn/Sall1^tm1Ryn; Sall2^tm1Ryn/Sall2^tm1Ryn
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:81008 )

• all die perinatally

renal/urinary system

abnormal kidney morphology ( J:81008 )

• severity or kidney abnormalities is comparable to that seen in single Sall1 homozygotes

kidney cyst ( J:81008 )

• the remnant kidneys have multiple cysts

small kidney ( J:81008 )

• exhibit reduced kidney size at E12.5

• 41.7% have two small remnant kidneys

absent kidney ( J:81008 )

• 25% have no kidneys or ureters bilaterally

single kidney ( J:81008 )

• 33.3% have unilateral kidney agenesis and hypoplasia on the other side

absent ureter ( J:81008 )

• 25% have no kidneys or ureters bilaterally

abnormal ureteric bud morphology ( J:81008 )

impaired branching involved in ureteric bud morphogenesis ( J:81008 )

• exhibit impaired ureteric branching at E12.5

growth/size/body

kidney cyst ( J:81008 )

• the remnant kidneys have multiple cysts