Phenotypes Associated with This Genotype

Genotype
MGI:3699199

• Allelic Composition: Sall4^tm1Ryn/Sall4^tm1Ryn
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:118119 )

• do not survive beyond E6.5

embryo

decreased inner cell mass proliferation ( J:118119 )

• cultured blastocysts show reduced outgrowth of the inner cell mass and a reduction in cell proliferation

• even in the absence of the trophectoderm, inner cell mass growth is reduced

abnormal embryonic epiblast morphology ( J:118119 )

• 26.9% of embryos at E5.5-6.5 barely retain a structure that resembles the epiblast

cellular

decreased inner cell mass proliferation ( J:118119 )

• cultured blastocysts show reduced outgrowth of the inner cell mass and a reduction in cell proliferation

• even in the absence of the trophectoderm, inner cell mass growth is reduced