Mouse Genome Informatics
involves: C57BL/6J
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• progressive axonal swelling is seen in the ascending and descending tracts of the white matter of the spinal cord beginning around 4 months of age
• swellings are restricted to the central nervous system
• focal swellings contain an accumulation of organelles
• in cultured cortical neurons axonal swellings are localized proximal to the region of transition between stable and dynamic microtubules

• at 22 months of age, but not at 4 or 12 months, the alteration coefficient is increased
• from 15 to 24 months of age mice display a larger decrease (35%) in critical speed compared to controls (17%)
• reduced step length at 22 months of age but, not at 4 or 12 months

reproductive system

Mouse Models of Human Disease
Spastic Paraplegia 4, Autosomal Dominant; SPG4 182601 J:117740