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Phenotypes Associated with This Genotype
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spasttm1.1Jme mutation (0 available); any Spast mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• progressive axonal swelling is seen in the ascending and descending tracts of the white matter of the spinal cord beginning around 4 months of age
• swellings are restricted to the central nervous system
• focal swellings contain an accumulation of organelles
• in cultured cortical neurons axonal swellings are localized proximal to the region of transition between stable and dynamic microtubules

• at 22 months of age, but not at 4 or 12 months, the alteration coefficient is increased
• from 15 to 24 months of age mice display a larger decrease (35%) in critical speed compared to controls (17%)
• reduced step length at 22 months of age but, not at 4 or 12 months

reproductive system

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hereditary spastic paraplegia 4 DOID:0110792 OMIM:182601

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory