Phenotypes Associated with This Genotype

Genotype
MGI:3699143

• Allelic Composition: Foxp3^tm1.1Ayr/Foxp3^tm1.1Ayr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

thymus hypoplasia ( J:125405 )

♀

enlarged spleen ( J:117743 )

♀ • observed in 3-week old mutants

abnormal T cell differentiation ( J:125405 )

♀ • the number of CD44+CD25- DN1 cells is increased

decreased double-positive T cell number ( J:125405 )

♀

lymph node inflammation ( J:117743 )

♀ • observed in 3-week old female mutants

increased susceptibility to autoimmune disorder ( J:117743 )

♀

liver inflammation ( J:117743 )

♀ • massive lymphocytic and mononuclear infiltrates in liver sinusoids of females seen at 3 weeks

lung inflammation ( J:117743 )

♀ • massive lymphocytic and mononuclear infiltrates in lung interstitium seen at 3 weeks

dermatitis ( J:117743 )

♀ • massive lymphocytic and mononuclear infiltrates in epidermis seen at 3 weeks in females; not seen in control littermates

hematopoietic system

thymus hypoplasia ( J:125405 )

♀

enlarged spleen ( J:117743 )

♀ • observed in 3-week old mutants

abnormal T cell differentiation ( J:125405 )

♀ • the number of CD44+CD25- DN1 cells is increased

decreased double-positive T cell number ( J:125405 )

♀

liver/biliary system

liver inflammation ( J:117743 )

♀ • massive lymphocytic and mononuclear infiltrates in liver sinusoids of females seen at 3 weeks

respiratory system

lung inflammation ( J:117743 )

♀ • massive lymphocytic and mononuclear infiltrates in lung interstitium seen at 3 weeks

integument

dermatitis ( J:117743 )

♀ • massive lymphocytic and mononuclear infiltrates in epidermis seen at 3 weeks in females; not seen in control littermates

scaly skin ( J:117743 )

♀ • tail scaling is observed

endocrine/exocrine glands

thymus hypoplasia ( J:125405 )

♀

growth/size/body

enlarged spleen ( J:117743 )

♀ • observed in 3-week old mutants