Phenotypes Associated with This Genotype

Genotype
MGI:3699096

• Allelic Composition: \Rag1^tm1Mom/\Rag1^tm1Mom; \Sh3bp2^tm1Bjro/\Sh3bp2^tm1Bjro
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * BALB/cJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoclast differentiation ( J:117880 )

• no change in abnormal osteoclast formation compared to mice homozygous for the Sh3bp2 allele alone

decreased bone mineral density ( J:117880 )

• decreased bone mineral density in the long bones at 10 weeks of age

• no improvement in bone loss compared to mice homozygous for the Sh3bp2 allele alone

immune system

abnormal osteoclast differentiation ( J:117880 )

• no change in abnormal osteoclast formation compared to mice homozygous for the Sh3bp2 allele alone

increased circulating tumor necrosis factor level ( J:117880 )

• serum levels of TNF are elevated similar to what is seen in mice homozygous for the Sh3bp2 allele alone

increased inflammatory response ( J:117880 )

• mice still develop the macrophage-rich inflammatory infiltrates in internal organs and periosteal regions that are seen in mice homozygous for the Sh3bp2 allele alone

homeostasis/metabolism

increased circulating tumor necrosis factor level ( J:117880 )

• serum levels of TNF are elevated similar to what is seen in mice homozygous for the Sh3bp2 allele alone

hematopoietic system

abnormal osteoclast differentiation ( J:117880 )

• no change in abnormal osteoclast formation compared to mice homozygous for the Sh3bp2 allele alone

cellular

abnormal osteoclast differentiation ( J:117880 )

• no change in abnormal osteoclast formation compared to mice homozygous for the Sh3bp2 allele alone