Phenotypes Associated with This Genotype

Genotype
MGI:3698842

• Allelic Composition: Tg(TcraH-Y,TcrbH-Y)71Vbo/0; Tnfrsf25^tm1Mjo/Tnfrsf25^tm1Mjo
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal thymus morphology ( J:84536 )

• by 14 weeks of age, thymus is almost undetectable in ~50% of the animals

increased thymocyte number ( J:84536 )

• at 10 weeks, significant inhibition of negative selection is observed; however, substantial negative selection occurs, as male thymi contain 1/100 the number of cells found in females

abnormal negative T cell selection ( J:84536 )

• at 10 weeks, significant inhibition of negative selection is observed; however, substantial negative selection occurs, as male thymi contain 1/100 the number of cells found in females

• positive selection is not impaired

immune system

abnormal thymus morphology ( J:84536 )

• by 14 weeks of age, thymus is almost undetectable in ~50% of the animals

increased thymocyte number ( J:84536 )

• at 10 weeks, significant inhibition of negative selection is observed; however, substantial negative selection occurs, as male thymi contain 1/100 the number of cells found in females

abnormal negative T cell selection ( J:84536 )

• at 10 weeks, significant inhibition of negative selection is observed; however, substantial negative selection occurs, as male thymi contain 1/100 the number of cells found in females

• positive selection is not impaired

endocrine/exocrine glands

abnormal thymus morphology ( J:84536 )

• by 14 weeks of age, thymus is almost undetectable in ~50% of the animals

increased thymocyte number ( J:84536 )

• at 10 weeks, significant inhibition of negative selection is observed; however, substantial negative selection occurs, as male thymi contain 1/100 the number of cells found in females