Mouse Genome Informatics
ht
    Htttm2.1Pfs/Htt+
involves: 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• exhibit heightened aggression amongst group housed males and females and increased incidence of isolation-induced aggression in the resident-intruder test

nervous system
• brains are, on average, 10-15% smaller at 4-6 months of age
• however, do not exhibit any pathological gliosis, ventricular enlargement, or neurodegeneration at 4-6 and 16-17 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Huntington Disease; HD 143100 J:54906