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Phenotypes Associated with This Genotype
Genotype
MGI:3698752
Allelic
Composition
Htttm1.1Pfs/Htt+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htttm1.1Pfs mutation (0 available); any Htt mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• exhibit heightened aggression amongst group housed males and females and increased incidence of isolation-induced aggression in the resident-intruder test

nervous system
• brains are, on average, 10-15% smaller at 4-6 months of age
• however, do not exhibit any pathological gliosis, ventricular enlargement, or neurodegeneration at 4-6 and 16-17 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Huntington's disease DOID:12858 OMIM:143100
J:54906


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/13/2017
MGI 6.10
The Jackson Laboratory