Phenotypes Associated with This Genotype

Genotype
MGI:3698725

• Allelic Composition: Tmie^sr/Tmie^sr
• Genetic Background: B6.B(CBA)-Tmie^sr/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:144656 )

• in an open-field test, mice remain in the center longer than wild-type mice

abnormal reflex ( J:116914 )

• abnormal drop reflex; mice do not demonstrate expected dorsoflexion and spread out the front paws when quickly lowered from ~20 cm above a table surface, while controls do exhibit this behavior

impaired balance ( J:144656 )

• mice exhibit impaired balance on a stationary rod compared to wild-type mice

impaired swimming ( J:116914 )

• mice exhibit poor swimming ability; mice can not maneuver in the water and can not remain at the surface

circling ( J:116914 , J:144656 )

• mice exhibit circling with a decreased latency to start circling compared to in cir homozygotes (J:144656)

hearing/vestibular/ear

absent linear vestibular evoked potential ( J:116914 )

• VESPs are absent at the maximum stimulus intensity used