Analysis Tools
hearing/vestibular/ear
|
• the stereocilia degenerate shortly after birth
• the stereociliary degeneration appeared consistently more advanced in inner hair cells than that of outer hair cells
|
|
• although stereocilia bundles were present at birth, the length and width of stereocilia at P0 were reduced
• the stereocilia on outer hair cells were significantly shorter
|
|
• at P0
|
|
• ABR assessment on homozygotes at 5 to 6 weeks of age shows no signs of hearing
|
|
• VESPs are absent at the maximum stimulus intensity used
|
behavior/neurological
|
• abnormal drop reflex; mice do not demonstrate expected dorsoflexion and spread out the front paws when quickly lowered from ~20 cm above a table surface, while controls do exhibit this behavior
|
|
• mice exhibit poor swimming ability; mice can not maneuver in the water and can not remain at the surface
|
nervous system
|
• the stereocilia degenerate shortly after birth
• the stereociliary degeneration appeared consistently more advanced in inner hair cells than that of outer hair cells
|
|
• although stereocilia bundles were present at birth, the length and width of stereocilia at P0 were reduced
• the stereocilia on outer hair cells were significantly shorter
|
|
• at P0
|
