Phenotypes for Htt MGI:3698411 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Htt^tm1Mem/Htt^tm6Mem
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htt^tm1Mem mutation (1 available); any Htt mutation (178 available)
Htt^tm6Mem mutation (0 available); any Htt mutation (178 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:72915 )

• exhibit movement abnormalities that are variable from week to week but do not worsen over time

• however, mutants do not develop paralysis or the progressive movement disorder seen in Hdh^tm6Mem and Hdh^tm8Mem compound heterozygotes

growth/size/body

decreased body size ( J:72915 )

• smaller throughout life

nervous system

enlarged lateral ventricles ( J:72915 )

• 3 of 7 adults have enlarged vesicles

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/28/2026 MGI 6.24