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Phenotypes Associated with This Genotype
Genotype
MGI:3698308
Allelic
Composition		 Lcktm1Dbs/Lcktm1Dbs
Tg(TcraTcrb)425Cbn/0
Genetic
Background		 involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcktm1Dbs mutation (0 available); any Lck mutation (96 available)
Tg(TcraTcrb)425Cbn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal positive T cell selection ( J:114660 )
• positive selection of CD4 and CD8 lineage is compromised
arrested T cell differentiation ( J:114660 )
• almost complete block of positive selection is observed

immune system
abnormal positive T cell selection ( J:114660 )
• positive selection of CD4 and CD8 lineage is compromised
arrested T cell differentiation ( J:114660 )
• almost complete block of positive selection is observed

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory