Phenotypes Associated with This Genotype

Genotype
MGI:3698248

• Allelic Composition: Prrx1^tm1Tex/Prrx1⁺; Prrx2^tm1Hubr/Prrx2^tm1Hubr
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:50488 )

• ~80% of newborns die within 24 hrs

• surviving newborns reach adulthood and appear healthy while most of their offspring survive with no problems

respiratory system

respiratory distress ( J:50488 )

• ~80% of newborns show respiratory problems

growth/size/body

palatal shelf hypoplasia ( J:50488 )

cleft secondary palate ( J:50488 )

• ~80% of newborns display a cleft secondary palate

distended abdomen ( J:50488 )

• ~80% of newborns display abdominal distension

craniofacial

palatal shelf hypoplasia ( J:50488 )

cleft secondary palate ( J:50488 )

• ~80% of newborns display a cleft secondary palate

digestive/alimentary system

palatal shelf hypoplasia ( J:50488 )

cleft secondary palate ( J:50488 )

• ~80% of newborns display a cleft secondary palate

skeleton

abnormal stylohyoid ligament morphology ( J:50488 )

• the stylohyoid ligament is chondrified