Phenotypes Associated with This Genotype

Genotype
MGI:3698170

• Allelic Composition: Tlr2^tm1Aki/Tlr2^tm1Aki
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell apoptosis ( J:135830 )

abnormal leukocyte migration ( J:171379 )

• Pam3Cys-treated mice exhibit reduced Ly6C^hi monocyte emigration from the bone marrow compared with similarly treated wild-type mice

abnormal macrophage physiology ( J:70578 , J:103464 , J:130138 )

• macrophages are unresponsive to macrophage activating lipopeptide 2 kD (MALP-2) and tripalitoyl cysteinyl lipopeptide (Pam₃CSK₄) (J:70578)

• response of macrophages to synthetic analogs of B. burgdorferi and T. pallidum lipopeptides is completely abrogated (J:70578)

• normal response of macrophages to lipopeptides of other bacterial origins (J:70578)

• activation by peptidoglycan, zymosan, and propionibacterium acnes fails (J:103464)

• reduced production of TNF alpha in response to Porphyromonas gingivalis (J:130138)

abnormal osteoclast physiology ( J:130138 )

• cultural supernatant from P gingivalis stimulated peritoneal macrophage fails to stimulate osteoclast formation

decreased circulating interleukin-1 beta level ( J:119941 )

• reduced after both 30 and 60 minutes of reperfusion following ventricular ischemia

decreased circulating tumor necrosis factor level ( J:119941 )

• reduced after 30 but not 60 minutes of reperfusion following ventricular ischemia

abnormal cytokine secretion ( J:70578 )

• cytokine production by macrophages in response to both diacylated (macrophage activating lipopeptide 2 kD [MALP-2]) and triacylated lipopeptides (tripalitoyl cysteinyl lipopeptide [Pam₃CSK₄]), and synthetic analogs of B. burgdorferi and T. pallidum lipopeptides) is completely abrogated

decreased interleukin-12 secretion ( J:70578 )

• macrophages produce no NO and IL-12 in response to MALP-2 together with IFN-gamma or to Pam₃CSK₄

decreased interleukin-6 secretion ( J:70578 )

• MEFs treated with MALP-2 or Pam₃CSK₄ fail to produce IL-6

decreased tumor necrosis factor secretion ( J:70578 , J:103395 )

• macrophages produce no TNF-alpha in response to MALP-2 or Pam₃CSK₄ (J:70578)

• macrophages show impaired TNF-alpha production in response to heat-killed mycoplasma (J:70578)

• macrophages show no TNF-alpha production in response to the native mycobacterial 19-kDa lipoprotein and a synthetic triacylated lipopeptide, but respond normally to diacylated lipoprotein (J:103395)

decreased inflammatory response ( J:146111 )

• leukocyte influx into cerebrospinal fluid occurs but is less than in controls after S. pneumoniae injection into the spinal canal

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:146111 )

• no deaths during the experimental period from meningitis induced by Streptococcus pneumoniae

muscle

muscle phenotype ( J:116310 )

N • MCP-1 (monocyte chemoattractant protein-1) release from isolated mouse aorta smooth muscle cells (MAoSMC) by stimulation with dsRNA is normal relative to controls

homeostasis/metabolism

abnormal response to cardiac infarction ( J:119941 )

• recovery of post-ischemic left ventricular contractile performance is greater than controls

decreased circulating interleukin-1 beta level ( J:119941 )

• reduced after both 30 and 60 minutes of reperfusion following ventricular ischemia

decreased circulating tumor necrosis factor level ( J:119941 )

• reduced after 30 but not 60 minutes of reperfusion following ventricular ischemia

decreased circulating alanine transaminase level ( J:135830 )

decreased cerebral infarct size ( J:128966 )

• relative infarction size is significantly smaller than in controls 72 hours after middle cerebral artery occlusion

liver/biliary system

abnormal hepatocyte morphology ( J:135830 )

• confluent foci of feathery hepatocyte degeneration due to bile acid cytotoxicity are significantly reduced compared to controls 24 hours after BDL

cardiovascular system

abnormal response to cardiac infarction ( J:119941 )

• recovery of post-ischemic left ventricular contractile performance is greater than controls

nervous system

decreased cerebral infarct size ( J:128966 )

• relative infarction size is significantly smaller than in controls 72 hours after middle cerebral artery occlusion

skeleton

abnormal osteoclast physiology ( J:130138 )

• cultural supernatant from P gingivalis stimulated peritoneal macrophage fails to stimulate osteoclast formation

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:146111 )

• no deaths during the experimental period from meningitis induced by Streptococcus pneumoniae

cellular

increased B cell apoptosis ( J:135830 )

abnormal leukocyte migration ( J:171379 )

• Pam3Cys-treated mice exhibit reduced Ly6C^hi monocyte emigration from the bone marrow compared with similarly treated wild-type mice

hematopoietic system

increased B cell apoptosis ( J:135830 )

abnormal leukocyte migration ( J:171379 )

• Pam3Cys-treated mice exhibit reduced Ly6C^hi monocyte emigration from the bone marrow compared with similarly treated wild-type mice

abnormal macrophage physiology ( J:70578 , J:103464 , J:130138 )

• macrophages are unresponsive to macrophage activating lipopeptide 2 kD (MALP-2) and tripalitoyl cysteinyl lipopeptide (Pam₃CSK₄) (J:70578)

• response of macrophages to synthetic analogs of B. burgdorferi and T. pallidum lipopeptides is completely abrogated (J:70578)

• normal response of macrophages to lipopeptides of other bacterial origins (J:70578)

• activation by peptidoglycan, zymosan, and propionibacterium acnes fails (J:103464)

• reduced production of TNF alpha in response to Porphyromonas gingivalis (J:130138)

abnormal osteoclast physiology ( J:130138 )

• cultural supernatant from P gingivalis stimulated peritoneal macrophage fails to stimulate osteoclast formation