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Phenotypes Associated with This Genotype
Genotype
MGI:3698040
Allelic
Composition
Htttm4Mem/Htt+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htttm4Mem mutation (2 available); any Htt mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• exhibit relocation of the mutant protein to the nucleus in medium sized spiny neurons and much later, the formation of morphologic nuclear inclusions and insoluble aggregate that are hallmarks of Huntington's Disease in humans, although at a slower rate than seen in homozygotes (J:60937)
• exhibit relocation of the mutant protein to the nucleus in medium sized spiny neurons and much later, the formation of morphologic nuclear inclusions and insoluble aggregate that are hallmarks of Huntington's Disease in humans, although at a slower rate than seen in homozygotes (J:60937)

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:60937


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory