Phenotypes Associated with This Genotype

Genotype
MGI:3698005

• Allelic Composition: Mad1l1^tm1.1Ktj/Mad1l1⁺
• Genetic Background: involves: BALB/c * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal chromosome number ( J:117337 )

• chromosomal instability is much higher than in wild-type MEFs

aneuploidy ( J:117337 )

• 6% of MEFs are aneuploid for chromosome 2 compared to 1.4% of wild-type MEFs

abnormal cell physiology ( J:117337 )

• mutant MEFs injected into athymic nude mice produced tumors in 3/8 mice compared to no tumors from wild-type MEFs; tumors grow slowly and are not palpable until weeks 6 to 10

abnormal mitotic spindle assembly checkpoint ( J:117337 )

• stringency of spindle assembly checkpoint (SAC) mediated arrest in response to nocodazole is weaker in mutant MEFs

neoplasm

increased tumor incidence ( J:117337 )

• when assayed at 18 moths of age, heterozygotes show increased tumor incidence compared to wild-type

• mutant MEFs induce tumors in 100% of athymic nude mice in 4 weeks

increased carcinoma incidence ( J:117337 )

• uterine carcinoma is observed in some mice at 18 months of age

increased hepatocellular carcinoma incidence ( J:117337 )

• observed in some mice at 18 months of age with higher incidence than in wild-type

increased lung adenocarcinoma incidence ( J:117337 )

• observed in some mice at 18 months of age with higher incidence than in wild-type

increased sarcoma incidence ( J:117337 )

• uterine sarcoma is observed in some mice at 18 months of age

increased rhabdomyosarcoma incidence ( J:117337 )

• observed in some mice at 18 months of age with higher incidence than in wild-type

increased hemangiosarcoma incidence ( J:117337 )

• observed in some mice at 18 months of age with higher incidence than in wild-type

increased osteosarcoma incidence ( J:117337 )

• observed in some mice at 18 months of age with higher incidence than in wild-type

skeleton

increased osteosarcoma incidence ( J:117337 )

• observed in some mice at 18 months of age with higher incidence than in wild-type

respiratory system

increased lung adenocarcinoma incidence ( J:117337 )

• observed in some mice at 18 months of age with higher incidence than in wild-type

muscle

increased rhabdomyosarcoma incidence ( J:117337 )

• observed in some mice at 18 months of age with higher incidence than in wild-type

liver/biliary system

increased hepatocellular carcinoma incidence ( J:117337 )

• observed in some mice at 18 months of age with higher incidence than in wild-type