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Phenotypes Associated with This Genotype
Genotype
MGI:3697910
Allelic
Composition		 Tg(Lck-Sox13)#Jskg/0
Genetic
Background		 involves: C57BL/6
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♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased thymocyte apoptosis ( J:117301 )
• frequency of apoptotic DP and gamma-delta TCR-positive thymocytes is increased 2-fold compared to littermates
decreased T cell proliferation ( J:117301 )
• a 2.5-fold decrease in BrdU incorporation is observed in thymocyte progenitors (triple negative (TN) cells)
decreased thymocyte number ( J:117301 )
• total thymocyte numbers are greatly reduced compared to littermate controls
decreased double-positive T cell number ( J:117301 )
• double-positive (DP) T cells are absent or nearly so in E17 transgenic mice and their development remains impaired through adult life

hematopoietic system
increased thymocyte apoptosis ( J:117301 )
• frequency of apoptotic DP and gamma-delta TCR-positive thymocytes is increased 2-fold compared to littermates
decreased T cell proliferation ( J:117301 )
• a 2.5-fold decrease in BrdU incorporation is observed in thymocyte progenitors (triple negative (TN) cells)
decreased thymocyte number ( J:117301 )
• total thymocyte numbers are greatly reduced compared to littermate controls
decreased double-positive T cell number ( J:117301 )
• double-positive (DP) T cells are absent or nearly so in E17 transgenic mice and their development remains impaired through adult life

cellular
increased thymocyte apoptosis ( J:117301 )
• frequency of apoptotic DP and gamma-delta TCR-positive thymocytes is increased 2-fold compared to littermates
decreased T cell proliferation ( J:117301 )
• a 2.5-fold decrease in BrdU incorporation is observed in thymocyte progenitors (triple negative (TN) cells)

endocrine/exocrine glands
increased thymocyte apoptosis ( J:117301 )
• frequency of apoptotic DP and gamma-delta TCR-positive thymocytes is increased 2-fold compared to littermates
decreased thymocyte number ( J:117301 )
• total thymocyte numbers are greatly reduced compared to littermate controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory