Phenotypes Associated with This Genotype

Genotype
MGI:3697594

• Allelic Composition: Pde3b^tm1Yhc/Pde3b^tm1Yhc
• Genetic Background: 129X1/SvJ-Pde3b^tm1Yhc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal fat cell morphology ( J:117353 )

• on normal chow diet, mean diameter of adipocytes is significantly lower than in wild-type; cell diameter distribution is shifterd to lower values

decreased gonadal fat pad weight ( J:117353 )

• on normal chow diet, weight of gonadal adipose tissue is less than in wild-type

decreased percent body fat/body weight ( J:117353 )

• on normal chow diet, adipose tissue represents lesser percentage of body weight

endocrine/exocrine glands

increased insulin secretion ( J:117353 )

• after treatement with beta-adrenergic receptor agonists, secretion is increased to a greater extent than in controls

growth/size/body

increased body weight ( J:117353 )

• 3-4 month old mice are slightly heavier than wild-type controls

homeostasis/metabolism

abnormal circulating hormone level ( J:117353 )

increased circulating insulin level ( J:117353 )

• after treatement with beta-adrenergic receptor agonists, levels are increased significantly more than in controls;

abnormal enzyme/coenzyme level ( J:117353 )

• livers show increased level of fatty acid synthase expression

• cAMP and phosphenolpyruvate carboxykinase levels are increased in livers of mutants

abnormal glucose homeostasis ( J:117353 )

• insulin-induced suppression of endogenous glucose production is lower in mutants (31% vs 89% in wild-type)

increased insulin secretion ( J:117353 )

• after treatement with beta-adrenergic receptor agonists, secretion is increased to a greater extent than in controls

insulin resistance ( J:117353 )

• mutants are insulin resistant; after treatment with beta-adrenergic receptor agonists, disposal of glucose is much lower than in treated wild-type

increased circulating adiponectin level ( J:117353 )

• serum adiponectin levels per white adipose tissue mass were markedly increased compared to wild-type

increased fatty acids level ( J:117353 )

• epididymal adipocytes from 6 month-old mutants treated with beta-adrenergic receptor agonists show higher levels

increased circulating free fatty acids level ( J:117353 )

• after treatement with beta-adrenergic receptor agonists, levels are increased compared to controls, indicating increased lipolysis

• levels are elevated in fasted mutants

increased glycerol level ( J:117353 )

• epididymal adipocytes from 6 month-old mutants treated with beta-adrenergic receptor agonists show higher levels

increased circulating glycerol level ( J:117353 )

• after treatement with beta-adrenergic receptor agonists, levels are increased compared to controls, indicating increased lipolysis

• levels are elevated in fasted mutants

increased triglyceride level ( J:117353 )

• on normal chow diet, content is significantly increased compared to controls

enhanced lipolysis ( J:117353 )

pigmentation

abnormal coat/hair pigmentation ( J:117353 )

• coat color of mutants varies from white to yellowish brown

integument

abnormal coat/hair pigmentation ( J:117353 )

• coat color of mutants varies from white to yellowish brown